Words that have the following combination of letters at the beginning of the word are often said in the following way:
| letter combination | sound | example | pronunciation |
| pt | t | pterygoid | |
| ps | s | psorias | |
| pn | n | pneometer | |
| gn | n | gnathitis | |
| mn | n | mnemonic |
however
If a prefix ending in a vowel comes before the following combination of letters then the first letter is pronounced:
| word | pronunciation |
| hemoptysis | |
| prognathism | |
| polypnea | |
| dysgnathia |
Combination of vowels
oe and ae (English spelling) are pronounced asee
. Ce/cae/coe as see and ge/gae/goe as jee in English.
| word | pronunciation |
| haema | he'mah |
| rugae | |
| coelum | |
| septicaemia | |
| caecum |
Another combination of letter are pronounced in the following way:
| Letter combination | sound | word | pronunciation |
| ph | f | phrenoplegia | |
| rh | r | rhytidosis | |
| ch | k | cochlea | |
| x | z | xanthic | |
| dys | dis | dysphagia |